Viral Population Estimation Using Pyrosequencing
نویسندگان
چکیده
منابع مشابه
Viral Population Estimation Using Pyrosequencing
The diversity of virus populations within single infected hosts presents a major difficulty for the natural immune response as well as for vaccine design and antiviral drug therapy. Recently developed pyrophosphate-based sequencing technologies (pyrosequencing) can be used for quantifying this diversity by ultra-deep sequencing of virus samples. We present computational methods for the analysis...
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Coarse codes are widely used throughout the brain to encode sensory and motor variables. Methods designed to interpret these codes, such as population vector analysis, are either ineecient, i.e., the variance of the estimate is much larger than the smallest possible variance, or biologically implausible, like maximum likelihood. Moreover, these methods attempt to compute a scalar or vector esti...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2008
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1000074